Basic Information
VIS ID
TVIS10008147
Fusion event
HBV-NPHP3-ACAD11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
132428758/132709914 (Hg38)
End
132428758/132709914 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
NPHP3-ACAD11
Nearest miRNA
hsa-let-7g/Upstream/723983; hsa-mir-1224/Downstream/1657890;
Nearest TSS
ENST00000440867/Upstream/14758; ENST00000489343/Downstream/6899;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/49115, chr3-CpG: 57/Downstream/11955
Upstream sequence
tgggtgcaccaaaatctcagaaatcactactgaagaacttatccatgtaaccaaaaaccatctgttccccaaaaactattgaaataaaaaaaCTAGAAGT
Downstream sequence
CTGTGGCCCATTAGAAGACCAAACAATGGGCTTGCTGTTCAGGCACACGTCCATATTTCAAGGCATTCCCTACAAAACTGACCCATGGGGCTCagataaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate