Basic Information
VIS ID
TVIS10008149
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1694
Orient
-
Integrated sequence
ACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCG| |ACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAA
Host Sequence
Chromosome
chr3
Cytoband
q25.33
Reference genome
GRCh37/hg19
Start
159467273/159749484 (Hg38)
End
159467273/159749484 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
IQCJ-SCHIP1 ; SCHIP1
miRNAs that regulate target gene
hsa-mir-98-5p
Nearest miRNA
hsa-let-7g/Upstream/466750; hsa-mir-1224/Downstream/655104;
Nearest TSS
ENST00000440867/Upstream/475729; ENST00000639448/Downstream/14229;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/946944, chr3-CpG: 166/Downstream/13673
Upstream sequence
caccagggccctcagtggggaatgtatccagcctatactgcttatcctcatccccaaaccctaaagcaactaagagggttccttggcataacaggtttct
Downstream sequence
TCCTTGGCCATTGCTGTGGATTTGTGTTCATCATGCTCCCAGCTCCCATCTTGCACTAGGTCGCGCTTTAGGTTGCTGGGCATTGTGTGCAACATTCCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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