Basic Information
VIS ID
TVIS10008156
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
18111912/18110289 (Hg38)
End
18111912/18110289 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/4482332; hsa-mir-12115/Downstream/2417986;
Nearest TSS
ENST00000502981/Upstream/88413; ENST00000511431/Downstream/379219;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/87639, chr4-CpG: 284/Downstream/2141364
Nearby gene
LCORL(-88429) ;
Upstream sequence
accctaaccctaaccctaaccctaaccctaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaacgctaaccctaaccctaaccct
Downstream sequence
ataaactagaaacaaagggacagtgtTATATATGCATGTGAATATACGTATACATCTGCACAGCACGTGCGTGCACGCACACACACTCACACATATTTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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