Basic Information
VIS ID
TVIS10008157
Fusion event
HBV-LOC105377609 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1776
Orient
-
Integrated sequence
CAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACT| |AGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCA
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
189363773/188442619 (Hg38)
End
189363773/188442619 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105377609
Nearest miRNA
hsa-mir-12113/Upstream/3504179;
Nearest TSS
ENST00000502981/Upstream/41883; ENST00000510832/Downstream/12959;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/159299, chr4-CpG: 31/Downstream/188612
Nearby gene
TRIML1(-295124) ; LINC01060(+12959) ;
Upstream sequence
GAATTTCCCATACTCGATGCTGTCTGCCCTTGGAAGCTGCTGGCTAATGTTTGGTTTTAACTGTGCTACCCTCTGCAGGTGGCTTTTTACTTCAATTACC
Downstream sequence
TGCAGCCTCACTGGAGGGGTCGTTTTCTGGAAGTGATATCTAACATCCCTCCATTATCTGGAAGTGATATCTAAAATCCCCACCATTATCTGAAAGTGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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