VISDB Viral Integration Site DataBase

VIS ID

TVIS10008163

Fusion event

HBV-EVC2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

724

Orient

-

Integrated sequence

GCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTG| |TTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTG

Chromosome

chr4

Cytoband

p16.2

Reference genome

Start

End

5613981/5612254 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-3942-3p ; hsa-mir-6873-3p ; hsa-mir-5100 ; hsa-mir-4722-5p ; hsa-mir-6721-5p ; hsa-mir-942-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-5088-3p ; hsa-mir-6729-3p ; hsa-mir-4768-3p ; hsa-mir-1245b-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p

Nearest miRNA

hsa-mir-4800/Upstream/3362098; hsa-mir-12113/Downstream/311021;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/43630, chr4-CpG: 56/Downstream/96004

Upstream sequence

gttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttgggttagggttggggttggggttggggttggggttgg

Downstream sequence

ttctctgcggtctgtatttcccaaacggcaattcccagtttttctcttggataaactcttgaaaactgggttctgattctttcaattatttcaggatgac