Basic Information
VIS ID
TVIS10008166
Fusion event
HBV-LOC102724832 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1777
Orient
-
Integrated sequence
AGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTA| |GGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAA
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74160316/73294599 (Hg38)
End
74160316/73294599 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC102724832
Nearest miRNA
hsa-mir-12113/Upstream/7017671; hsa-mir-1243/Downstream/3278969;
Nearest TSS
ENST00000502981/Upstream/35390; ENST00000510166/Downstream/102515;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/35186, chr4-CpG: 20/Downstream/325728
Nearby gene
ANKRD17(-35814) ; ALB(+109656) ;
Upstream sequence
GCTGACTTCCTCTAGTAGGCCATCTTATAGGTCCACCTTATACCACATAATAGTGTAATTAAAAAGCGCTGATGTTGGGTACCAGGAAGAATCTGCCCTC
Downstream sequence
attcgattgtgattttatgacaatatagttatttgcataagttcaataagagtcttttaaacagaacaattagagacactgattcctttaccaagacttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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