Basic Information
VIS ID
TVIS10008171
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
-
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr5
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
153879099/154499539 (Hg38)
End
153879099/154499539 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/152292; hsa-mir-103a-1/Downstream/96473;
Nearest TSS
ENST00000502646/Upstream/13389; ENST00000518892/Downstream/213363;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/5871, chr5-CpG: 49/Downstream/110858
Nearby gene
HAND1(-21275) ; MIR3141(+96473) ;
Upstream sequence
TTAAATTATTCCTTTTTATCTTCAATTGTTTATACAGGTTTAACGGCAACAATCTTAACTAACAACAAGTAATGCCCTGGCTATTTATTGTACCATCGCA
Downstream sequence
CTCACTTAGGCCCCAATCTGCCAAGGTCATATATTTAAAATGTGGTTCCAAATGTCTTTCCTCAAATAGCCATTATttgaacacaaagaacatataggct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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