Basic Information
VIS ID
TVIS10008180
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1710
Orient
-
Integrated sequence
TGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTT| |CAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCA
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
45716368/45748631 (Hg38)
End
45716368/45748631 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-10398/Upstream/550861; hsa-mir-10524/Downstream/6395718;
Nearest TSS
ENST00000381078/Upstream/171861; ENST00000321037/Downstream/188833;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/84554, chr6-CpG: 72/Downstream/266509
Nearby gene
RUNX2(-197549) ; CLIC5(+149822) ;
Nearest cancer related gene
RUNX2(TSG, -197549) ;
Upstream sequence
AAAGgtgtgtgtgcatctgtgtgtgtgtgtgtgtgtgtgtgtTTACAGGTCTGTGAGTGAGCTGAAGAATAACAACTAACACCTTCGAGATAGCTAGCTG
Downstream sequence
gactgtaatttccttgagactgaggagtatgtgttcttctgtatctctagggctcacatctaatatttgattaataagcctggagaatggataaaAGGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate