Basic Information
VIS ID
TVIS10008182
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
92117304/91407586 (Hg38)
End
92117304/91407586 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6G
Nearest miRNA
hsa-mir-10398/Upstream/1094753; hsa-mir-1202/Downstream/114074;
Nearest TSS
ENST00000381078/Upstream/14586; ENST00000452624/Downstream/282842;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/796086, chr6-CpG: 92/Downstream/2008968
Nearby gene
MAP3K7(-820284) ; MIR4643(+114074) ;
Nearest cancer related gene
MAP3K7(OG, -820284) ;
Upstream sequence
tgtgaccagactggccaacatggtgaaaccctgtctttactaaaaatacaaaaattagctgggcgtggttgtgggcgcctgtaatcccagctactcagga
Downstream sequence
atgttcctgcaaaggacatgatctcgctcctttttatggctgcatgtattccatggtgtatatgttccaaattttctttatccagtctaccattcttggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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