VISDB Viral Integration Site DataBase

VIS ID

TVIS10008185

Fusion event

HBV-NRF1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2277

Orient

+

Integrated sequence

TATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGG| |ATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAA

Chromosome

chr7

Cytoband

q32.2

Reference genome

Start

End

129336064/129696224 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-320a ; hsa-mir-4772-5p ; hsa-mir-3127-5p ; hsa-mir-6823-5p ; hsa-mir-6798-5p ; hsa-mir-383-5p ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-377-3p ; hsa-mir-5579-3p ; hsa-mir-2115-5p ; hsa-mir-1277-5p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-1249-5p ; hsa-mir-6797-5p ; hsa-mir-765 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4487 ; hsa-mir-4756-5p ; hsa-mir-3192-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-4779 ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-6083 ; hsa-mir-3912-5p ; hsa-mir-297 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-6834-3p ; hsa-mir-380-3p ; hsa-mir-4495 ; hsa-mir-379-3p ; hsa-mir-411-3p ; hsa-mir-7108-5p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-663b ; hsa-mir-7155-3p ; hsa-mir-3136-3p ; hsa-mir-33a-3p ; hsa-mir-3692-3p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-183-3p ; hsa-mir-5701 ; hsa-mir-6776-5p ; hsa-mir-140-3p ; hsa-mir-944 ; hsa-mir-504-3p

Nearest miRNA

hsa-mir-10525/Upstream/1488281; hsa-mir-10399/Downstream/74159;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/83624, chr7-CpG: 53/Downstream/66156

Nearest cancer related gene

NRF1(TSG, No orient, 0)

Upstream sequence

CTCTAGCCATAAAGCCCATCAAAAACCAAAAGATTGTCTACTTAGTGGTAAAAAATAATAACGACGATGATAGGAGGATTCTGCTGAACTCATGTTTTCA

Downstream sequence

acaagagcgaaactccgtctcaaagaaaataaaaataaataaataaaGTGCAAAGTTTGATAATGTTTCTGCTTTGTTTTACGCAAAGATTACTTTATGT