Basic Information
VIS ID
TVIS10008189
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1945
Orient
+
Integrated sequence
TCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGT| |TACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTG
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
62496239/63035861 (Hg38)
End
62496239/63035861 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7J
Nearest miRNA
hsa-mir-1183/Upstream/5630771; hsa-mir-10399/Downstream/585229;
Nearest TSS
ENST00000635602/Upstream/5585684; ENST00000418297/Downstream/18570;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/654964, chr7-CpG: 49/Downstream/18276
Nearby gene
ZNF733P(+255431) ;
Upstream sequence
ccagtccagcccggctaacatagtgaaaccccgtctccactaaaaaataaaaaatcagcccggcatggttgtgggcgcctgtaatcccagctactcagga
Downstream sequence
AACACCTCTACAGCTCTTTGTATGACAAAGTTATGAATGATTTGACCTGTTACACATAACATACATAATATGATATAAAGCTGCTATCAGCATGGACTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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