Basic Information
VIS ID
TVIS10008191
Fusion event
HBV-STEAP2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
89599864/89970550 (Hg38)
End
89599864/89970550 (Hg38)
Orient
-
Location type
Intronic
Target gene
STEAP2-AS1
Nearest miRNA
hsa-mir-10525/Upstream/14055281; hsa-mir-10399/Downstream/2233465;
Nearest TSS
ENST00000635602/Upstream/526576; ENST00000475789/Downstream/152340;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1210581, chr7-CpG: 98/Downstream/148028
Nearby gene
ZNF804B(-633518) ; DPY19L2P4(+148850) ;
Upstream sequence
CTCTAGCCATAAAGCCCATCAAAAACCAAAAGATTGTCTACTTAGTGGTAAAAAATAATAACGACGATGATAGGAGGATTCTGCTGAACTCATGTTTTCA
Downstream sequence
ctatagttcacattgttatacattagctatccagagcttatttaactagcataagtgaaattctgtaccccttgaccaacatctccccatatcctcctcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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