Basic Information
VIS ID
TVIS10008194
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
140524828/139512585 (Hg38)
End
140524828/139512585 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/4707640; hsa-mir-10400/Downstream/1219979;
Nearest TSS
ENST00000518652/Upstream/49569; ENST00000518354/Downstream/89479;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/634381, chr8-CpG: 17/Downstream/106268
Nearby gene
COL22A1(-598592) ; KCNK9(+99976) ;
Upstream sequence
gtggggcctcagaatgatgtcacttggctccctggattcagcccccttcctagggaaatgcacggatttatctcccgatttgctggaattctcggggcag
Downstream sequence
GACAGAGCTCTGACCAGAAAGAACATGTCCCCAGCAATGGTGTGTCCTGGCCTGGGGTAAAAACTGTTCTCATTACCCAGGGGAATTGGCTCCATGAGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate