Basic Information
VIS ID
TVIS10008197
Fusion event
HBV-FLJ39630 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2228
Orient
-
Integrated sequence
TGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCAC| |TTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACA
Host Sequence
Chromosome
chr8
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
63807129/62894570 (Hg38)
End
63807129/62894570 (Hg38)
Orient
-
Location type
Intronic
Target gene
FLJ39630
Nearest miRNA
hsa-mir-124-1/Upstream/1179711; hsa-mir-10400/Downstream/1484579;
Nearest TSS
ENST00000518652/Upstream/420301; ENST00000622794/Downstream/83291;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/645065, chr8-CpG: 91/Downstream/143993
Upstream sequence
agccaccactcccagccTGCCCAGTTCTTTTTAAAATAAAATTGTATAATGGGTTCACCTAAGACTGACTGATTCTCCACATCTGGAAACCTGGGAACTC
Downstream sequence
CTTTAAACCAGGGCATAGTTCACCTCTCCAGAGGCAGCAGCTGCTATCAGTTCTTTGGATAAACTTCCAGAAATATTACATACATATAAGTATCACTTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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