Basic Information
VIS ID
TVIS10008199
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1793
Orient
-
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
79036625/78124390 (Hg38)
End
79036625/78124390 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1157540; hsa-mir-10400/Downstream/1207798;
Nearest TSS
ENST00000518652/Upstream/673693; ENST00000521879/Downstream/23711;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1123569, chr8-CpG: 46/Downstream/391808
Nearby gene
PEX2(-1123345) ; PKIA(+391711) ;
Upstream sequence
ATATGACCATCAAATCTTAACTTTTAGTCAAACTAAGGTCTTGAATGAATTGGATTGATAAAATTATGGTGTTTTATTTCTTGTAGTTGTTGTTCTTTTA
Downstream sequence
TAGGGTGATTATTGACCCTGAGCAGAAGAATAAAAAAGAAAACAAAATAATTGACTAATTTTGACCATCCAATTTAGTCAAAATGGTGATCCCTGCAGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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