Basic Information
VIS ID
TVIS10008201
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr9
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
109316463/106554182 (Hg38)
End
109316463/106554182 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/8324965; hsa-mir-12126/Downstream/46746;
Nearest TSS
ENST00000422679/Upstream/103366; ENST00000444985/Downstream/37770;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/859027, chr9-CpG: 55/Downstream/305961
Nearby gene
TMEM38B(-779019) ; ZNF462(+308915) ;
Upstream sequence
TGTAATGTGGGGTTTTATTGCAAAGAATGGCAAGATTTTTAGGCTTATTTTCTGAAAATTCTCCCTGTGTTTGGGGAACAGTCACAGAATGTGGAGGAAT
Downstream sequence
ctaatatctggcacaaggcaaagatgctcactctcacgacctctactcaacatagtgctagaagtcatagctaaagtaattagaaaataaaaaataatca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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