Basic Information
VIS ID
TVIS10008204
Fusion event
HBV-LOC101927042 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2355
Orient
+
Integrated sequence
TTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGA| |CGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGT
Host Sequence
Chromosome
chr9
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
65780201/38952237 (Hg38)
End
65780201/38952237 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101927042
Nearest miRNA
hsa-mir-101-2/Upstream/2058706; hsa-let-7a-1/Downstream/1976773;
Nearest TSS
ENST00000422679/Upstream/148230; ENST00000473440/Downstream/133911;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/329603, chr9-CpG: 42/Downstream/126455
Nearby gene
SPATA31A5(-270591) ; PTGER4P2(+714068) ;
Upstream sequence
ATCTCTGCCTGAAGCAGATTTCCTGTCAGCTTCTTTGCTTCATGACAATGAACTGAAACCAGAGGAGACACTCAAGCAGAGGCCAGGTGGCCTTGAAGTA
Downstream sequence
ACCATAAAATATGGTACCTTGACATTTGAGGAAACTGAAGAagaaatatcactctatgactgtccctgatcctccttcctaaaagcatgtcctaaaacct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate