Basic Information
VIS ID
TVIS10008205
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chrX
Cytoband
q24
Reference genome
GRCh37/hg19
Start
116819325/117685362 (Hg38)
End
116819325/117685362 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/2861798; hsa-mir-105-1/Downstream/701032;
Nearest TSS
ENST00000429181/Upstream/991174; ENST00000493448/Downstream/262580;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1716298, chrX-CpG: 74/Downstream/430908
Nearby gene
CT83(-1225188) ; KLHL13(+212451) ;
Upstream sequence
tgtccacttgcagattctgccaaaagaatatttcaaaactgctctatgaaaagcaatgttaaacttggcggctcgaacacaaacatcacaaagcagtttc
Downstream sequence
TAATGATGGCAAATACCATGGGCAGAAAACAACACTGTGAATCTCTCCAACACCATCAAGGTTTTTCTCTTCTTTTCTCACTCTAGGGAAAACCTGTACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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