Basic Information
VIS ID
TVIS10008215
Fusion event
HBV-LOC100996442 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2451
Orient
-
Integrated sequence
ACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGT| |TAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAAT
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
162086/162086 (Hg38)
End
162086/162086 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC100996442
Nearest miRNA
hsa-mir-1302-2/Upstream/131583; hsa-mir-101-1/Downstream/25805;
Nearest TSS
ENST00000473358/Upstream/1640; ENST00000412666/Downstream/196771;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/26523, chr1-CpG: 104/Downstream/37165
Nearby gene
LOC729737(-21520) ; LOC100133331(+161806) ;
Upstream sequence
TCAAATCCTAGATCCTAGGTCTGCTTGGTAGCATGCTTCCTAGGTAGTGGATCTGAGGCTACCTATAGAACTTCCTTTGCAGTCATAGTTCGCTCAGAAA
Downstream sequence
CTACAAAAGTGCTTGCTCTTGAAAATGGAgtctttgtccatttcatgcttctataaaagaataccacagactgcataatttataaaaaggaaaaaaggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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