VISDB Viral Integration Site DataBase

VIS ID

TVIS10008216

Fusion event

HBV-CHRM3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

618

Orient

+

Integrated sequence

CCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCA| |TCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCC

Chromosome

chr1

Cytoband

q43

Reference genome

Start

End

240072840/239909540 (Hg38)

Orient

+

Location type

downstream

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-296-3p ; hsa-mir-2467-3p ; hsa-mir-6878-5p ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-5197-3p ; hsa-mir-6758-5p ; hsa-mir-4311 ; hsa-mir-1277-5p ; hsa-mir-4776-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-5011-5p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-137 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-670-5p ; hsa-mir-4445-5p ; hsa-mir-6766-3p ; hsa-mir-4782-3p ; hsa-mir-219a-5p ; hsa-mir-508-3p ; hsa-mir-339-5p ; hsa-mir-6079 ; hsa-mir-5186 ; hsa-mir-4522 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-6888-5p ; hsa-mir-148a-5p ; hsa-mir-4428 ; hsa-mir-8075 ; hsa-mir-4728-3p

Nearest miRNA

hsa-mir-101-1/Upstream/2438349; hsa-mir-3123/Downstream/1222732;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/521501, chr1-CpG: 105/Downstream/87997

Upstream sequence

GAATATAAAGAAATTTATTCTGAAATAGACTTTACGTGTTTTTTTCTTAAAGAGGAGAAAAATATTGCTTGACGGCAATTATATACCCAAAGTGATTTGC

Downstream sequence

CTGGGTCCTTTAATTCCCATTAGCTTTGGAATCTCAGATGAGCATAGCTGACCCAGTTCCCACATTCTTCCCAAGGATCCCAAAAGTGGGAATCCAGACC