VISDB Viral Integration Site DataBase

VIS ID

TVIS10008219

Fusion event

HBV-EPS8 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1844

Orient

+

Integrated sequence

GGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCAT| |CTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAG

Chromosome

chr12

Cytoband

p12.3

Reference genome

Start

End

15863525/15710591 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-552-5p ; hsa-mir-589-3p ; hsa-mir-4262 ; hsa-mir-892c-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-606 ; hsa-mir-543 ; hsa-mir-1273f ; hsa-mir-129-5p ; hsa-mir-3529-5p ; hsa-mir-379-5p ; hsa-mir-4451 ; hsa-mir-4534 ; hsa-mir-4650-3p ; hsa-mir-6832-5p ; hsa-mir-8082

Nearest miRNA

hsa-mir-1244-3/Upstream/2794673; hsa-let-7i/Downstream/1962708;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/387624, chr12-CpG: 104/Downstream/78193

Nearest cancer related gene

EPS8(OG, No orient, 0)

Upstream sequence

GAGACAATATTTCACAAATTGCTTTTGCATTTTAGAAAATATATTGAGCATTAAAACTACCACAAGTTTTTTCTAATCAAATTAACAAACCTAGTTAATA

Downstream sequence

TATTTTGTACACACGATTCTGTATAAAAATGCCACAAATTTAACCGACGTATAATTTCTTCATGTAGCTGGAAAGTCAATTTTTAAGTGCTTACATGTCA