Basic Information
VIS ID
TVIS10008224
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
41913160/41443957 (Hg38)
End
41913160/41443957 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/4491566; hsa-mir-1185-1/Downstream/6317038;
Nearest TSS
ENST00000550708/Upstream/489059; ENST00000553926/Downstream/160899;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/2010955, chr14-CpG: 47/Downstream/162698
Nearby gene
LRFN5(+163604) ;
Upstream sequence
ATATACACTACATTTTGATAATCATTTTATCTTCAGAGCTTATATGTGGCACATAGTTTATTAGTTTTTACCTCATCCATAATTATGGTATTATCAACTT
Downstream sequence
AATGATACCTAAGTGTTTCCTTTCTCTTTAAATAAATTTAACAGTAACTTGGCTATTTTAAATGATTTATATACTACTATTTGAATTTATCAAATTTATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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