Basic Information
VIS ID
TVIS10008226
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2688
Orient
+
Integrated sequence
AGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAA| |GGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGA
Host Sequence
Chromosome
chr14
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
55965963/55499245 (Hg38)
End
55965963/55499245 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/621052; hsa-mir-1185-1/Downstream/4147717;
Nearest TSS
ENST00000550708/Upstream/42519; ENST00000557267/Downstream/59827;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/58530, chr14-CpG: 158/Downstream/80671
Nearby gene
TBPL2(-58700) ; KTN1-AS1(+76912) ;
Upstream sequence
TGctctctgtctctgtctgtctctctctctctctcCCCACCCCTTTCACAACAGCTAAGATATAAATAATCCTGGCCAGCAGGGCAGCTCTGTTCTCTTG
Downstream sequence
TTATTCAACAACCCAGGTTATTTCTAAACCGTAGCTCTGCATTGTCATTATCTGCATAATATGATAAAAGTATATGGATTCTAGATGGAGGGAAGGGAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate