Basic Information
VIS ID
TVIS10008227
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
72298951/71832234 (Hg38)
End
72298951/71832234 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/4390304; hsa-mir-1185-1/Downstream/684586;
Nearest TSS
ENST00000550708/Upstream/102042; ENST00000555581/Downstream/16372;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/510726, chr14-CpG: 114/Downstream/99713
Nearby gene
SIPA1L1(-92831) ; RGS6(+99866) ;
Upstream sequence
gcaattctcctgcctcagcctccctagtagctgggattacaggtgtgcaccaccatgcctgactaatttttgtatttttagtagagatggggtttcacca
Downstream sequence
tgttggccaggctggtctggaactcctgacctcagatcatctgcccgccttggcctcccaaagtgttgggattacaggtgtgagtcaacatgcctagcca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate