VISDB Viral Integration Site DataBase

VIS ID

TVIS10008231

Fusion event

HBV-TOM1L2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1949

Orient

-

Integrated sequence

GTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACT| |CTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCA

Chromosome

chr17

Cytoband

p11.2

Reference genome

Start

End

17828037/17924723 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-148b-3p ; hsa-mir-130b-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-3161 ; hsa-mir-8075 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4728-3p ; hsa-mir-513b-3p ; hsa-mir-186-3p ; hsa-mir-5003-5p ; hsa-mir-3714 ; hsa-mir-224-5p ; hsa-mir-548an ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4313 ; hsa-mir-670-5p ; hsa-mir-3943

Nearest miRNA

hsa-mir-1253/Upstream/110792; hsa-mir-10226/Downstream/416091;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/84049, chr17-CpG: 73/Downstream/47130

Nearest cancer related gene

TOM1L2(TSG, No orient, 0)

Upstream sequence

catggtggtacatgcctgtagtccccagctactcaagaggctgagataggagtattgcttcagcacggaagactgaggctgcagcgaaccgtgatcacat

Downstream sequence

cactgcactccagcctgagggacagagtgagaccctgcctcaaaaataaaataaaattcttaaaacttctcaaatataaaataaaaaagtgatgattaaa