VISDB Viral Integration Site DataBase

VIS ID

TVIS10008238

Fusion event

HBV-USP37 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1959

Orient

-

Integrated sequence

TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG| |CCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATA

Chromosome

chr2

Cytoband

q35

Reference genome

Start

End

219327981/218463258 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-19b-3p ; hsa-mir-30c-5p ; hsa-let-7e-5p ; hsa-mir-4487 ; hsa-mir-8060 ; hsa-mir-302b-5p ; hsa-mir-302d-5p ; hsa-mir-6820-3p ; hsa-mir-3164 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-4501 ; hsa-mir-185-3p ; hsa-mir-4709-3p ; hsa-mir-3591-5p ; hsa-mir-616-3p ; hsa-mir-3119 ; hsa-mir-5580-5p ; hsa-mir-215-3p ; hsa-mir-4280 ; hsa-mir-142-3p ; hsa-mir-6832-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-4775 ; hsa-mir-130b-5p ; hsa-mir-5003-3p ; hsa-mir-32-3p ; hsa-mir-606 ; hsa-mir-6894-3p ; hsa-mir-19a-3p ; hsa-mir-4763-5p ; hsa-mir-6828-5p ; hsa-mir-891a-5p ; hsa-mir-4772-3p ; hsa-mir-4264 ; hsa-mir-1910-5p ; hsa-mir-455-3p ; hsa-mir-191-5p ; hsa-mir-548av-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p

Nearest miRNA

hsa-mir-10b/Upstream/60536; hsa-mir-1244-1/Downstream/359832;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/56512, chr2-CpG: 106/Downstream/104786

Upstream sequence

gctctcccccacaataaacacacacacacacacacacacacacacacacacacacacacacacacacacacactttctttatatgttcttctatgtgtga

Downstream sequence

atggtaattttaccattaaaaaaatgtaattaaaaAGATCTCCACACCTTGAAGACTTAACTCGGTAGCTCTTTTGAGGTCATCATCTTCTTTCTGTTCC