Basic Information
VIS ID
TVIS10008241
Fusion event
HBV-LARGE1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1429
Orient
-
Integrated sequence
GGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTA| |CGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGC
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
34268819/33872831 (Hg38)
End
34268819/33872831 (Hg38)
Orient
-
Location type
Intronic
Target gene
LARGE1
miRNAs that regulate target gene
hsa-mir-18a-5p
Nearest miRNA
hsa-mir-1286/Upstream/436162; hsa-let-7a-3/Downstream/1462809;
Nearest TSS
ENST00000624155/Upstream/11207; ENST00000610170/Downstream/556;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/222220, chr22-CpG: 275/Downstream/47022
Upstream sequence
tcatgcctgtaatcccagcactttgggaggctgaggcgggtggatgacctgaggtcaggagttcgagaccagcctggccaacatggcaaaaccctgtctc
Downstream sequence
tactgaaaacacaaaaaaataagctgggtgtggtggcagacacctgtaatcccagctactcgggaggctgaggcaggagaattgcctgaacccatgaggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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