APOL3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008242
Fusion event
HBV-APOL3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
+
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
36562733/36166685 (Hg38)
End
36562733/36166685 (Hg38)
Orient
+
Location type
upstream
Fragile sites / regions
FRA22A
Target gene
APOL3
Nearest miRNA
hsa-mir-1286/Upstream/829886; hsa-let-7a-3/Downstream/120162;
Nearest TSS
ENST00000624155/Upstream/508; ENST00000475519/Downstream/35192;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/100322, chr22-CpG: 24/Downstream/155720
Upstream sequence
CAGTCCCGTGGCTAAGAAGGCGTGCTGTCGGATTGCTGGCGGACTTTTCTGCTTTACCCCAGGCAGAAGGGTTTTGAGAGGGGCTGAACCCTGACCAACA
Downstream sequence
TGACCCTTTCACTGGGAACTGTTTCATCCTGGGCAAATGTCCCTGCAGCCTCGTGGCCACCACCCCATACACCTGCCAGATTTTCAGGGAGGAACAGGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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