APOL3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008243
Fusion event
HBV-APOL3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1751
Orient
-
Integrated sequence
TTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGG| |AGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGT
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
36562744/36166696 (Hg38)
End
36562744/36166696 (Hg38)
Orient
-
Location type
upstream
Fragile sites / regions
FRA22A
Target gene
APOL3
Nearest miRNA
hsa-mir-1286/Upstream/829897; hsa-let-7a-3/Downstream/120151;
Nearest TSS
ENST00000624155/Upstream/519; ENST00000475519/Downstream/35181;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/100333, chr22-CpG: 24/Downstream/155709
Upstream sequence
CTAAGAAGGCGTGCTGTCGGATTGCTGGCGGACTTTTCTGCTTTACCCCAGGCAGAAGGGTTTTGAGAGGGGCTGAACCCTGACCAACATGACCCTTTCA
Downstream sequence
CTGGGAACTGTTTCATCCTGGGCAAATGTCCCTGCAGCCTCGTGGCCACCACCCCATACACCTGCCAGATTTTCAGGGAGGAACAGGAGGGTGATTACAc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate