Basic Information
VIS ID
TVIS10008244
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2399
Orient
+
Integrated sequence
GACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACG| |AAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTC
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
62363398/62377723 (Hg38)
End
62363398/62377723 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA3B
Nearest miRNA
hsa-let-7g/Upstream/1759853; hsa-mir-12124/Downstream/4847741;
Nearest TSS
ENST00000440867/Upstream/3399; ENST00000465262/Downstream/27152;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/316, chr3-CpG: 23/Downstream/619
Nearby gene
FEZF2(-4208) ; CADPS(+20623) ;
Upstream sequence
caggTGTGGCTGATGGctctggctttggctgcctgacgtttcctggatcctgcagcgtggcacaggacacatttgcctcctggttgccttctggacttgc
Downstream sequence
TCTTGCGGTGTAGACAACCTCAGAAGAAAATCCCTTTCTTGCGCAAAAAGCTCACACATTTGCACCACGGAAGAAAAAGGCAAGCATTTCCACTCCAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate