Basic Information
VIS ID
TVIS10008249
Fusion event
HBV-LOC105377771 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2451
Orient
-
Integrated sequence
ACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGT| |TAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAAT
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
180724750/181297749 (Hg38)
End
180724750/181297749 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105377771
Nearest miRNA
hsa-mir-10397/Upstream/75116;
Nearest TSS
ENST00000502646/Upstream/16374; ENST00000604669/Downstream/8753;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/15902, chr5-CpG: 29/Downstream/29655
Nearby gene
TRIM52(-36631) ; LOC100133331(+25757) ;
Upstream sequence
CTGGGCCGCGCTTCCCCGCCCGCGCGCCGCTCGCGCTCCCAGGGTGCAGGGACGCCAGCGAGGGCCCCAGCGGAGAGAGGTCGAATCGGCCTAGGCTGTG
Downstream sequence
TCTGAGCGAACTATGACTGCAAAGGAAGTTCTATAGGTAGCCTCAGATCCACTACCTAGGAAGCATGCCACCAAGCAGACCTAGGATCTAGGATTTGATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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