Basic Information
VIS ID
TVIS10008251
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1771
Orient
-
Integrated sequence
ACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTT| |GTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGC
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
94799677/94089959 (Hg38)
End
94799677/94089959 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/2568222; hsa-mir-1202/Downstream/3934572;
Nearest TSS
ENST00000381078/Upstream/203059; ENST00000424506/Downstream/73961;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/670000, chr6-CpG: 69/Downstream/1487406
Nearby gene
TSG1(-313478) ; MANEA(+1225696) ;
Upstream sequence
aaatgtctaactaaaaatatgtcctagcaaagatatggagtatctaaaactctcataacgctggtgggaatataagataatacactctggaaaatagttt
Downstream sequence
AGTAATTTAAAAACTCCTTCACTTCTTTCCTCGATGAAAGGCATGCAGAGCATAATTGGGTGCTATTGTGGTAGACAGcatttggtgtgattattcttga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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