Basic Information
VIS ID
TVIS10008263
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
+
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
188626072/188656941 (Hg38)
End
188626072/188656941 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/8218551; hsa-mir-1182/Downstream/4059387;
Nearest TSS
ENST00000473358/Upstream/148403; ENST00000445072/Downstream/53939;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1975992, chr1-CpG: 56/Downstream/4151561
Nearby gene
PLA2G4A(-1667959) ; BRINP3(+1440725) ;
Upstream sequence
tcatctagagATCCTGAAAAAAAAACAAAAGAAAAGCCATTTATTCATTCCACAAAAATTGTTGAAGTGCTTCTTATGGTCTTCAAATAGTTACTGCTGC
Downstream sequence
TTTCTGCAGGCACATTTCTTGAACTAAAGGATAAAACAATATTACCAAGATTCACAAATGATTCTAAAAAAATATTGGTGATTCTAAGACAGAAGGCATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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