VISDB Viral Integration Site DataBase

VIS ID

TVIS10008266

Fusion event

HBV-ZNF669 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1703

Orient

-

Integrated sequence

CGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGG| |CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG

Chromosome

chr1

Cytoband

q44

Reference genome

Start

End

247267270/247103968 (Hg38)

Orient

-

Location type

Exonic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-302a-5p ; hsa-mir-4649-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-4459 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-302f ; hsa-mir-6771-3p ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-376b-3p ; hsa-mir-376a-3p ; hsa-mir-600 ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-296-3p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-6845-3p ; hsa-mir-4452 ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-4302 ; hsa-mir-4712-5p ; hsa-mir-770-5p ; hsa-mir-3682-5p ; hsa-mir-1911-5p ; hsa-mir-6771-5p ; hsa-mir-7160-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6746-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-378a-5p ; hsa-mir-193b-5p ; hsa-mir-1193 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-2392 ; hsa-mir-1229-3p ; hsa-mir-1306-5p ; hsa-mir-329-5p ; hsa-mir-4422 ; hsa-mir-4680-5p ; hsa-mir-4761-5p ; hsa-mir-548e-5p ; hsa-mir-6511a-3p ; hsa-mir-6511b-3p ; hsa-mir-6784-3p ; hsa-mir-6862-3p ; hsa-mir-1278 ; hsa-mir-1297 ; hsa-mir-155-3p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-4272 ; hsa-mir-4465 ; hsa-mir-4698 ; hsa-mir-5580-3p ; hsa-mir-5697 ; hsa-mir-8063

Nearest miRNA

hsa-mir-101-1/Upstream/3757713; hsa-mir-3124/Downstream/97999;

Nearest TSS

Nearest CpG islands

chr1-CpG: 58/Target, None/Upstream, None/Downstream

Upstream sequence

CTGGAACCCCGCACACCGAGACACCGAGTCGGGGCTCTCCCGCATCACCCTCCCGTGGTCACCACACTACCTGGATAGGGGAGGCGAGGGGTTCCCGACA

Downstream sequence

GGGCTCCGGCCGGCGGAAGTGGCGCCCGCAGGTACAGACAGGATGCAGGGGTTCCGCTgcccgccccgcccggcccggcccTGAACAGAAGAGGACTGAG