Basic Information
VIS ID
TVIS10008270
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
249240220/248946021 (Hg38)
End
249240220/248946021 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1I
Nearest miRNA
hsa-mir-101-1/Upstream/119578;
Nearest TSS
ENST00000473358/Upstream/39649;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/39230, None/Downstream
Nearby gene
PGBD2(-26875) ;
Upstream sequence
gttagggttaggggttagggttagggttagggttagggttagggttagggtagggttagggttagggttagggttagggttagggttagggttagggtag
Downstream sequence
ggttagggttagggttagggttagggttagggttaggggttagggttagggttagggttagggttagggttagggttagggttgggttagggttagggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate