Basic Information
VIS ID
TVIS10008274
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2385
Orient
-
Integrated sequence
TCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCC| |TCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTT
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135524466/133787141 (Hg38)
End
135524466/133787141 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/415478;
Nearest TSS
ENST00000439456/Upstream/160346;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/25894, None/Downstream
Nearby gene
DUX4L8(-25974) ;
Upstream sequence
taacaggcatattactcatggagggttagggttcaggttcgggtacgggttcaggttcgggttcgggttcgggttccggttcgggttaggggttagggtt
Downstream sequence
gggttagggttagggttagggttagggttagggttagggttagggtttagggtcagggtcagggtcagggtcagggtcagggtcagggttaggggttagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate