Basic Information
VIS ID
TVIS10008282
Fusion event
HBV-LOC388572 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
175777/175777 (Hg38)
End
175777/175777 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC388572
Nearest miRNA
hsa-let-7a-2/Downstream/33559;
Nearest TSS
ENST00000527297/Upstream/36165; ENST00000342878/Downstream/17303;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/48000, chr11-CpG: 184/Downstream/31198
Nearby gene
LINC01001(-43857) ; SCGB1C1(+17303) ;
Upstream sequence
caaccctaaccctagcccctaatcctaaccctaacccctaacccctaacactaaccctaaccctaacgctaaccctaaccctaaccctaaccctaaccct
Downstream sequence
aacccaaccctaaccctagcccctaatcctaaccctaacccctaacccctaacactaaccctaaccctaacgctaacgctaaccctaaccctaaccctaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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