Basic Information
VIS ID
TVIS10008284
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1103
Orient
+
Integrated sequence
GGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCG| |CCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCA
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
34382985/34361438 (Hg38)
End
34382985/34361438 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11E
Nearest miRNA
hsa-mir-210/Upstream/5883890; hsa-let-7a-2/Downstream/580399;
Nearest TSS
ENST00000527297/Upstream/3430; ENST00000528104/Downstream/77487;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2275, chr11-CpG: 58/Downstream/77180
Nearby gene
ABTB2(-3430) ; CAT(+77487) ;
Nearest cancer related gene
CAT(TSG, +77487) ;
Upstream sequence
GAGAGCAttacctgcttgtttgttggttgtctttctgtcctacaagaatataagctccatgagggaagggatcttctccattgagttcacttttgtatcc
Downstream sequence
cattgcctaggtcagtatgagcgtaaagtaggagctcaataaatattgaataagtgaatgaatGAAACTAACAGGATGAATGGGGCAATGTAATGAACAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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