VISDB Viral Integration Site DataBase

VIS ID

TVIS10008286

Fusion event

HBV-PHF21A integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

398

Orient

+

Integrated sequence

GTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTAT| |CATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCA

Chromosome

chr11

Cytoband

p11.2

Reference genome

Start

End

46132644/46111093 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-221-3p ; hsa-mir-548c-3p ; hsa-mir-7855-5p ; hsa-mir-216a-5p ; hsa-mir-129-5p ; hsa-mir-1909-3p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-4468 ; hsa-mir-6081 ; hsa-mir-6132 ; hsa-mir-6722-3p ; hsa-mir-6754-5p ; hsa-mir-6836-5p ; hsa-mir-759

Nearest miRNA

hsa-mir-129-2/Upstream/419317; hsa-let-7a-2/Downstream/265309;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/187871, chr11-CpG: 65/Downstream/8735

Upstream sequence

aggctggtctcgaactcttgacctcaggtgatccacccgcctcagcctaccaaagagctgggattacaggcgtgagccaccgcgcctggccATATTAACA

Downstream sequence

AATTTTAAATCACAACTATGTGGGGGGGGAGGCTAGTATTATTACAGCAGATTGGTTTGCTATATAAACAAGTACTTTAAAAAATATTTCTTGggccagg