VISDB Viral Integration Site DataBase

VIS ID

TVIS10008287

Fusion event

HBV-PHF21A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1061

Orient

-

Integrated sequence

TATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCT| |TTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGC

Chromosome

chr11

Cytoband

p11.2

Reference genome

Start

End

46132935/46111384 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-221-3p ; hsa-mir-548c-3p ; hsa-mir-7855-5p ; hsa-mir-216a-5p ; hsa-mir-129-5p ; hsa-mir-1909-3p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-4468 ; hsa-mir-6081 ; hsa-mir-6132 ; hsa-mir-6722-3p ; hsa-mir-6754-5p ; hsa-mir-6836-5p ; hsa-mir-759

Nearest miRNA

hsa-mir-129-2/Upstream/419608; hsa-let-7a-2/Downstream/265018;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/188162, chr11-CpG: 65/Downstream/8444

Upstream sequence

catggtgaaaccccatctctactaaaaatataacaattagccaggcatggaggtgcatgcctgtaattccagctgctcgagaggctgaggcatgagaact

Downstream sequence

gctggatcctgggaggcagaggttgcagtgagctgatattgcgccactgcactccatatccagcctgggcaacatggcaagactccgtctcaaataaata