Basic Information
VIS ID
TVIS10008298
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
+
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
22999862/22846928 (Hg38)
End
22999862/22846928 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/5173534; hsa-let-7i/Downstream/1365493;
Nearest TSS
ENST00000382841/Upstream/59885; ENST00000629078/Downstream/12237;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/221649, chr12-CpG: 92/Downstream/1715094
Nearby gene
ETNK1(-156254) ; SOX5(+685369) ;
Upstream sequence
CCCAATATTTTGTATAATAGTAATAGGACAAAAAACCCACAGGAACACTCACAGTTTTACAAACCAAGAAGAAAATGTCACCAGCCATTGACTGTCATAT
Downstream sequence
ATGAACATATTATTTGGCATGTAGCAGGCTGACAAATCTACAGCATCTACACAGTCAAGGGCTTGGTGTAATACAATTTCTCTAGGTTAAAATTAACTCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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