VISDB Viral Integration Site DataBase

VIS ID

TVIS10008311

Fusion event

HBV-RB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

554

Orient

+

Integrated sequence

ATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTAT| |GTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCC

Chromosome

chr13

Cytoband

q14.2

Reference genome

Start

End

48916909/48342773 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-106a-5p ; hsa-mir-26a-5p ; hsa-mir-23b-3p ; hsa-mir-335-5p ; hsa-mir-106b-5p ; hsa-mir-675-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-192-5p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-149-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-221-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-892a ; hsa-mir-3152-3p ; hsa-mir-4318 ; hsa-mir-4325 ; hsa-mir-3614-5p ; hsa-mir-4693-5p ; hsa-mir-6513-5p ; hsa-mir-26b-5p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-1258 ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-494-3p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-141-3p ; hsa-mir-590-5p

Nearest miRNA

hsa-mir-2276/Upstream/4146573; hsa-mir-1267/Downstream/1653642;

Nearest TSS

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/23052, chr13-CpG: 96/Downstream/189502

Nearest cancer related gene

RB1(TSG, No orient, 0)

Upstream sequence

TCGTTCACTTTTACTGAGCTACAGAAAAACATAGAAATCAGGTAAAGTTTCTTGTATAAATATAAGCCTCTGCCATAAAAGGAAACGAATTCTGGATTTT

Downstream sequence

CCTCTCAATAGACTTTTGTGAATTAGTGAGAAATGCTAAAATAAAGTAAAACAAAAAGAACTTGGACCAAATAGTGAACTGCCATTCTCTCATGGAGCCG