Basic Information
VIS ID
TVIS10008315
Fusion event
HBV-NRDE2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
508
Orient
+
Integrated sequence
TTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCA| |CGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCC
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
90766405/90300061 (Hg38)
End
90766405/90300061 (Hg38)
Orient
-
Location type
Intronic
Target gene
NRDE2
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-196a-5p
Nearest miRNA
hsa-mir-1260a/Upstream/13033771; hsa-mir-1185-1/Downstream/3648165;
Nearest TSS
ENST00000550708/Upstream/11176; ENST00000615251/Downstream/2776;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/43103, chr14-CpG: 36/Downstream/31759
Upstream sequence
AGTAAATAAGAAACTTTATTCCAAAGTTGTCATGTAAATGCTTTGGAATCACATGTGCTATTCGTGTTTAAAACCTCAAGCACGAGGATCGGGGTCTCCC
Downstream sequence
AACACTTTAGAGCAGTGGTCTTCGATGGGTCACATTTGTAGGCAGAACCCTCCACCCATCACTCTGTTCTTATCACAGAGGGTCTTAGGAAAGGGGCAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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