Basic Information
VIS ID
TVIS10008320
Fusion event
HBV-LOC105371082 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1747
Orient
-
Integrated sequence
GGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGG| |GAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTC
Host Sequence
Chromosome
chr16
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
11356934/11263077 (Hg38)
End
11356934/11263077 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105371082
Nearest miRNA
hsa-mir-1225/Upstream/5630511; hsa-mir-11401/Downstream/43363;
Nearest TSS
ENST00000527434/Upstream/6877; ENST00000572992/Downstream/6255;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/6131, chr16-CpG: 23/Downstream/13005
Nearby gene
SOCS1(-6895) ; TNP2(+4780) ;
Upstream sequence
gatcgaccccatgctccttaagaactgcatgatactcctcagcgtatgttcatttagccgtccccggtgggtggacacataggttgtatttttgctcttg
Downstream sequence
caaacagcgtggcctgcacctccctgtacagcctcttggcacacatgtgATAAACCGTTCTTACCGTTTGAATGTTCATAGGTGCCACCCAGTCACCTGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate