Basic Information
VIS ID
TVIS10008326
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
451
Orient
+
Integrated sequence
CCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGG| |ACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTC
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
17345171/17441857 (Hg38)
End
17345171/17441857 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1253/Upstream/1159769; hsa-mir-10226/Downstream/371623;
Nearest TSS
ENST00000595228/Upstream/96588; ENST00000585041/Downstream/35129;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/57799, chr17-CpG: 23/Downstream/35004
Nearby gene
MED9(+35129) ;
Upstream sequence
gataaacaagtgaacaaaggtctctggttttcctaggcagaggaccctgcggccttcagcagtgtttgtgtccctgggtacttgagattagggagtggtg
Downstream sequence
acgactcttaacgagcatgctgccttcaagcatctgtttaacaaagcacatcttgcaccgcccttaatccatttaaccctgagtggacacagcacatgtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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