Basic Information
VIS ID
TVIS10008327
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
677
Orient
-
Integrated sequence
AACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAG| |TTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGC
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
23682635/26102671 (Hg38)
End
23682635/26102671 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/1780925; hsa-mir-122/Downstream/488796;
Nearest TSS
ENST00000575820/Upstream/11454; ENST00000415576/Downstream/31181;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/11360, chr18-CpG: 25/Downstream/31093
Nearby gene
SS18(-12024) ; PSMA8(+31181) ;
Nearest cancer related gene
SS18(OG, -12024) ;
Upstream sequence
agtagctagaagagatttggaatgttcccaacacaagaaatgataaatgcttgaggtgatagatatcccacttacccagatttgatcattatacattgta
Downstream sequence
tgcatgtgtcaaaataccatatgtaaaccagaaatatgggcaatcattatgtatcaatTTTTAAAAATTAACCGTATTTagaaccttagagacctgcagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate