Basic Information
VIS ID
TVIS10008330
Fusion event
HBV-TUBB8P12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
63728/63728 (Hg38)
End
63728/63728 (Hg38)
Orient
+
Location type
Intronic
Target gene
TUBB8P12
Nearest miRNA
hsa-mir-1-2/Downstream/48528;
Nearest TSS
ENST00000575820/Upstream/14171; ENST00000580410/Downstream/9789;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/14073, chr18-CpG: 51/Downstream/9334
Nearby gene
ROCK1P1(+45337) ;
Upstream sequence
ctaaccctaaccccaaaccctaaccctagccctagccttagccctaaccctaaccctaacccctaaccctaaccctaaccctaacactaaccctaacccc
Downstream sequence
taaccctaactctaaccctaaccctagccctaaccctaaccctagccctagccttagccctaaccgttacgctaaccctaacccctaaccctaaccctaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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