Basic Information
VIS ID
TVIS10008335
Fusion event
HBV-RNU6-66P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
562
Orient
-
Integrated sequence
ATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCT| |CCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCG
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
46758278/46255021 (Hg38)
End
46758278/46255021 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA19A
Target gene
RNU6-66P
Nearest miRNA
hsa-mir-10395/Upstream/235972; hsa-let-7e/Downstream/454261;
Nearest TSS
ENST00000633603/Upstream/24633; ENST00000524533/Downstream/42025;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/175835, chr19-CpG: 43/Downstream/41775
Upstream sequence
TTACCATGCCCTACAGGAATAGCCACAAACTTGATGATTCACTTTTAGGCAACAGATCTGGTTCCTTGGTTAACCAGTCCGGTTTCTTTAGCTTCCTTCC
Downstream sequence
TTCCTGGAGGTTTTCCTATTCCGTTGTTAAGTGGGGCCAATGCCAAAAAGAAATTAGGGCAATCCCTGCTAGAGTATCTATCACCTTAATAGATTTCCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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