Basic Information
VIS ID
TVIS10008338
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2360
Orient
-
Integrated sequence
TGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGG| |CAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCC
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
59118901/58607534 (Hg38)
End
59118901/58607534 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-let-7e/Upstream/57158;
Nearest TSS
ENST00000633603/Upstream/8179;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/25628, None/Downstream
Nearby gene
MGC2752(-23139) ;
Upstream sequence
gttcagcacagacctggggggttagggttaggggtgccgttggggttggggttggggttagggttaggggttagggttagggttagggtttagggttagg
Downstream sequence
gtttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttNNNNNNNNNNNNNNNNNN
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate