VISDB Viral Integration Site DataBase

VIS ID

TVIS10008339

Fusion event

HBV-ANAPC1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

236

Orient

-

Integrated sequence

TTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCAC| |AATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCAC

Chromosome

chr2

Cytoband

q13

Reference genome

Start

End

112622362/111864785 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2B

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-100-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-4668-3p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-1226-5p ; hsa-mir-4279 ; hsa-mir-6868-3p ; hsa-mir-4721 ; hsa-mir-3616-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-1266-3p ; hsa-mir-548c-3p

Nearest miRNA

hsa-mir-1285-2/Upstream/93651; hsa-mir-10b/Downstream/1718174;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/640027, chr2-CpG: 63/Downstream/18975

Nearest cancer related gene

ANAPC1(TSG, No orient, 0)

Upstream sequence

gtcctgacctcaagtgatccgcctgccttggcctcccaaaatgctaggattacaggtgtgagccagtgcacccagccTACCCTTTCCTATTAAGGAGAAG

Downstream sequence

TGACTTGCCTTTCTCCTTACCTCTGATTTGACTCTCCGGAGAGTCCACACAGAATGCACATTTTGAACAGCATCATAAGTCATTACAATAGAGGGGTCAG